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KMID : 0043320080310040503
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Archives of Pharmacal Research
2008 Volume.31 No. 4 p.503 ~ p.510
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Prostaglandin Dysregulation of Proinflammatory Cytokine Production in Pristane-Induced Lupus Mice
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Shin Tae-Yong
Leem Jae-Yoon
Yang Jae-Heon
Kim Dae-Keun
Eun Jae-Soon
Chae Byeong-Suk
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Abstract
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Systemic lupus erythematosus (SLE) is characterized by inflammatory and dysregulatory immune responses including overactive B cells, overproduction of proinflammatory cytokines, and T cell hyperactivity. modulates a variety of immune processes at sites of inflammation, including production of inflammatory cytokines. However, the role of in dysregulatory inflammatory and immune responses in lupus remains unclear. We investigated whether mediates production of inflammatory cytokines in pristane-induced lupus BALB/c mice. Our results showed that levels of serum and BAL and LPS-stimulated production of by peritoneal macrophages were remarkably increased in pristane-induced lupus mice compared to healthy controls. Exogenous enhanced production of IL-6, IL-10, and NO but decreased by macrophages and augmented , IL-6, and IL-10 by splenocytes from pristane-induced lupus mice compared to healthy controls. Exogenous also enhanced production of , IL-6, and IL-10 by thymocytes from pristane-induced lupus mice. Indomethacin (Indo), a synthesis inhibitor, greatly inhibited LPS-induced production of IL-6 and IL-10 by macrophages from pristane-induced lupus mice, while enhanced . Indo remarkably inhibited Con A-increased production of , IL-6, and IL-10 by splenocytes and thymocytes from pristane-induced lupus mice. Therefore, our findings suggest that endogenous may mediate dysregulation of production of proinflammatory cytokines, such as IL-6, IL-10, and , and NO in pristane-induced lupus mice.
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KEYWORD
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lupus, IL-6, IL-10, NO, Pristane
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